Learn / Metabolism
Metabolic pathways
Every FMK pathway as a clickable map. Pick one pathway to hammer it — next step, enzyme, regulator, cofactor, and the facts that get tested (NADPH and who needs it, rate-limiting steps, deficiencies) — or set it to all pathways for a mixed drill. Every answer says which enzyme and which pathway.
NADPH — sources and what needs it · Cytosol (HMP shunt, malic enzyme), with mitochondrial and ER users. Enzymes sit beside the arrows, ★ = rate-limiting, ⊕/⊖ = activators/inhibitors (toggle), −ATP +NADH = what the step spends and makes (toggle ⚡), dashed = allosteric signal, shaded bands = compartment. Drag to pan.
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NADPH — sources and what needs it
NADPH oxidase (respiratory burst)
Made from NADPH by NADPH oxidase
NADPH oxidase — NADPH — sources and what needs it
O₂ → O₂⁻ → H₂O₂ → HOCl (myeloperoxidase). Defective in chronic granulomatous disease → catalase-positive infections (S. aureus, Aspergillus).
Condition cards:Chronic granulomatous disease (CGD) →