Learn / Metabolism

Metabolic pathways

Every FMK pathway as a clickable map. Pick one pathway to hammer it — next step, enzyme, regulator, cofactor, and the facts that get tested (NADPH and who needs it, rate-limiting steps, deficiencies) — or set it to all pathways for a mixed drill. Every answer says which enzyme and which pathway.

Pathway

Fructose metabolism · Liver (90% first-pass); minor in muscle/adipose via hexokinase. Enzymes sit beside the arrows, ★ = rate-limiting, ⊕/⊖ = activators/inhibitors (toggle), −ATP +NADH = what the step spends and makes (toggle ⚡), dashed = allosteric signal, shaded bands = compartment. Drag to pan.

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Fructose metabolism

DHAP

Made from Fructose-1-phosphate by Aldolase B ★

Aldolase B ★ rate-limiting — Fructose metabolism

Deficiency: Hereditary fructose intolerance — F1P accumulates, traps Pi → ↓ATP → gluconeogenesis and glycogenolysis fail: vomiting, hypoglycemia, jaundice, hepatomegaly after fruit/sucrose; avoid fructose, sucrose AND sorbitol

The regulated step of hepatic fructose handling.

Condition cards:Hereditary fructose intolerance (HFI) →

Becomes Glycolysis / gluconeogenesis via Triose phosphate isomerase → glycolysis

Triose phosphate isomerase → glycolysis — Fructose metabolism