Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.1
Uricosuric agents (probenecid, sulfinpyrazone) Acquired / not inherited
Defect / target: Block renal tubular urate reabsorption (URAT1; widely known)
Mechanism: Increase renal uric acid excretion, lowering serum urate below its saturation point (~6.5 mg/dL) to prevent crystal formation in under-excretors.
↑ Accumulates: Urinary uric acid· ↓ Deficient: Serum uric acid
Presentation: Long-term therapy for under-excretors of uric acid
Learn the mechanism: Purine degradation & uric acid →
FMK 08.1 Nucleic Acid Metabolism · slide 20