Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Signaling · FMK 01.2
Type 2 diabetes / insulin resistance Acquired / not inherited
Defect / target: Insulin (peptide hormone) deficiency or insulin receptor resistance
Mechanism: Loss of control over protein production produces transcriptional dysregulation of metabolic genes; cited as the metabolic-disease example of failed gene regulation.
↑ Accumulates: Blood glucose· ↓ Deficient: Insulin action
Presentation: chronic hyperglycemia and downstream complications; early T2DM: hyperinsulinemia with excess glycogenesis; dawn phenomenon (overnight glucagon/cortisol → morning glucose rise)
Labs: Fasting glucose >=126 mg/dL, HbA1c >=6.5%
Treatment: Insulin, oral hypoglycemics, lifestyle
Glucose homeostasis via insulin/glucagon negative feedback (01.3)
Learn the mechanism: Glycolysis →
FMK 01.2 Proteins, Carbohydrates, Lipids; FMK 06.3 Gene Regulation – Eukaryotes; FMK 02.1 Glucose Transport, Glycolysis & TCA · slide 01.2: 8; 06.3: When Gene Regulation Fails; Conclusion; 02.1: 5, 6, 24, 25; FMK 03.6 slide 27