Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Nucleotide · FMK 08.1
Tumor lysis syndrome (TLS) Acquired / not inherited
Defect / target: Massive lysis of leukemic/lymphoma cells after chemotherapy (secondary purine overproduction)
Mechanism: Lysis of huge numbers of tumor cells releases massive quantities of nucleic acid that are degraded to uric acid, along with intracellular potassium and phosphate, creating a life-threatening metabolic emergency.
↑ Accumulates: Uric acid, potassium, phosphate· ↓ Deficient: Calcium
Presentation: Acute kidney injury from urate nephropathy, hyperkalemia (arrhythmia), hyperphosphatemia, hypocalcemia after starting chemotherapy
Labs: Markedly elevated uric acid, potassium, phosphate; rising creatinine
Treatment: Rasburicase (recombinant urate oxidase, first-line in TLS) rapidly degrades uric acid to soluble allantoin; hydration
Learn the mechanism: Purine degradation & uric acid →
FMK 08.1 Nucleic Acid Metabolism · slide 16, 19, 20