Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Carbohydrate · FMK 01.6
Sucrose intolerance (sucrase-isomaltase deficiency) Autosomal recessive
Defect / target: Sucrase-isomaltase (brush-border alpha-glucosidase)
Mechanism: Without sucrase-isomaltase, sucrose (and alpha-1,6 branch products) is not hydrolyzed to glucose + fructose and is fermented in the colon.
↑ Accumulates: Undigested sucrose in colon; H2/CH4/CO2 gas· ↓ Deficient: Sucrase-isomaltase
Presentation: Osmotic diarrhea, bloating, cramping after sucrose; congenital (rare, prevalent in Inuit of Greenland) or acquired from small-intestinal inflammation
Labs: Positive hydrogen breath test after sucrose load
Treatment: Sucrose restriction, enzyme (sacrosidase) supplementation
Learn the mechanism: Carbohydrate digestion & absorption →
FMK 01.6 Carbohydrate Digestion & Absorption · slide ~20