Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 01.2
Statins (HMG-CoA reductase inhibition) Acquired / not inherited
Defect / target: HMG-CoA reductase (rate-limiting enzyme of cholesterol synthesis)
Mechanism: Lower intracellular cholesterol activates SREBP-2, which upregulates LDL receptors — the actual mechanism of plasma LDL lowering; liver-targeted because it dominates circulating supply.
· ↓ Deficient: Hepatic cholesterol synthesis
Presentation: Used for FH/hypercholesterolemia; adverse: myopathy, hepatotoxicity
Labs: Lower LDL-C
HMG-CoA reductase = the PFK-1 of cholesterol synthesis
Learn the mechanism: Cholesterol synthesis →
FMK 01.2 Proteins, Carbohydrates, Lipids; FMK 05.1 Cholesterol & Steroid Synthesis · slide 01.2: 12; 05.1: 2, 6, 8, 12; FMK 04.4 slide 21, 30