Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 02.1
SGLT-2 inhibitors (gliflozins: empagliflozin, dapagliflozin) Acquired / not inherited
Defect / target: SGLT-2 Na⁺-coupled glucose transporter in the proximal kidney tubule (normally reabsorbs ~90% of filtered glucose)
Mechanism: Blocking renal glucose reabsorption causes glucosuria, lowering blood glucose and weight with cardioprotection.
↑ Accumulates: urinary glucose
Presentation: T2DM therapy: glucosuria, ↓ blood glucose, ↓ weight, cardioprotection
Labs: glucosuria
Learn the mechanism: Glycolysis →
FMK 02.1 Glucose Transport, Glycolysis & TCA · slide 6, 25