Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 02.4
Aspirin (salicylate) overdose Acquired / not inherited
Defect / target: Partial uncoupling of OXPHOS + inhibition of TCA enzymes
Mechanism: High-dose salicylates partially uncouple oxidative phosphorylation and inhibit TCA enzymes, causing fever and metabolic acidosis after an early respiratory alkalosis.
↑ Accumulates: salicylate, lactate· ↓ Deficient: ATP
Presentation: fever, tachypnea, tinnitus
Labs: respiratory alkalosis early → anion-gap metabolic acidosis
Treatment: Urinary alkalinization, hemodialysis if severe
Learn the mechanism: Electron transport & OXPHOS →
FMK 02.4 Mitochondrial Metabolism and Energy Disorders · slide 13, 14, 25