Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Heme · FMK 08.4
Rotor syndrome Autosomal recessive
Defect / target: Defective hepatic storage / OATP transport of bilirubin
Mechanism: Impaired hepatocyte uptake/storage of bilirubin allows conjugated bilirubin to escape into plasma despite normal conjugation, without hepatic pigment deposition.
↑ Accumulates: Conjugated (direct) bilirubin· ↓ Deficient: Hepatic bilirubin uptake/storage
Presentation: Benign conjugated hyperbilirubinemia, liver NOT pigmented
Labs: Conjugated hyperbilirubinemia, normal liver enzymes
Treatment: None needed
Rotor = Regular-looking liver (distinguishes from Dubin-Johnson)
Learn the mechanism: Heme degradation & bilirubin (jaundice) →
FMK 08.4 Heme Metabolism · slide 28