Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.1
Rasburicase (recombinant urate oxidase) Acquired / not inherited
Defect / target: Supplies urate oxidase, the enzyme humans and other primates lack
Mechanism: Rapidly degrades uric acid to the far more soluble allantoin, lowering uric acid in high-risk patients.
↑ Accumulates: Allantoin (soluble, excreted)· ↓ Deficient: Uric acid
Presentation: First-line in tumor lysis syndrome
Labs: Rapid fall in serum uric acid
Humans lack urate oxidase — that is why uric acid, not allantoin, is our end product and why gout exists
Learn the mechanism: Purine degradation & uric acid →
FMK 08.1 Nucleic Acid Metabolism · slide 16, 20