Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Heme · FMK 08.4
Physiologic neonatal jaundice Acquired / not inherited
Defect / target: Developmentally immature UGT1A1 at birth (not a mutation)
Mechanism: Low bilirubin-UGT activity for ~2 weeks after birth, combined with increased RBC turnover (fetal hemoglobin breakdown, short neonatal RBC lifespan), raises unconjugated bilirubin transiently.
↑ Accumulates: Unconjugated bilirubin· ↓ Deficient: Conjugated bilirubin (transient)
Presentation: Affects ~60% of term and ~80% of preterm infants; appears day 2-3 of life, resolves within 1-2 weeks; jaundice in the first 24 hours is NEVER physiologic
Labs: Unconjugated hyperbilirubinemia
Treatment: Phototherapy (blue light converts bilirubin to water-soluble photoisomers such as lumirubin, excreted without conjugation); exchange transfusion if severe; sometimes phenobarbital to induce UGT
Day 1 jaundice = pathologic; day 2-3 = physiologic
Learn the mechanism: Heme degradation & bilirubin (jaundice) →
FMK 08.4 Heme Metabolism · slide 29; handout