Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Other · FMK 08.4
Pancreatic head cancer (malignant biliary obstruction) Acquired / not inherited
Defect / target: Tumor compressing/obstructing the distal common bile duct
Mechanism: A mass in the pancreatic head obstructs bile outflow, producing post-hepatic conjugated hyperbilirubinemia with a distended, non-fibrotic gallbladder.
↑ Accumulates: Conjugated bilirubin· ↓ Deficient: Stercobilin, urine urobilinogen
Presentation: Painless jaundice in an older adult, palpable non-tender gallbladder (Courvoisier sign), pale stool, dark urine, pruritus
Labs: Conjugated hyperbilirubinemia, elevated ALP/GGT
Treatment: Surgical resection/biliary decompression
Courvoisier sign = palpable non-tender gallbladder + painless jaundice = think malignancy, not stones
Learn the mechanism: Heme degradation & bilirubin (jaundice) →
FMK 08.4 Heme Metabolism · slide 25, 27; handout