Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.1
Mycophenolic acid (mycophenolate) Acquired / not inherited
Defect / target: Inhibits IMP dehydrogenase (first step of the GMP branch from IMP)
Mechanism: Blocks GMP synthesis, preferentially affecting rapidly proliferating T and B lymphocytes, which depend on de novo purine synthesis; used as an immunosuppressant to prevent transplant graft rejection.
↑ Accumulates: IMP· ↓ Deficient: GMP/GTP in lymphocytes
Presentation: Used for: transplant immunosuppression; side effects: GI upset, leukopenia, infections
IMP -> GMP branch requires ATP; IMP -> AMP branch requires GTP (cross-regulation)
Learn the mechanism: Purine synthesis & salvage →
FMK 08.1 Nucleic Acid Metabolism · slide 10, 29