Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 02.4
Metformin-associated lactic acidosis Acquired / not inherited
Defect / target: Mild Complex I inhibition; AMPK activation; ↓ hepatic glucose output/lactate clearance
Mechanism: Metformin accumulates in renal failure, inhibits Complex I and impairs hepatic lactate clearance (Cori cycle), producing Type B lactic acidosis.
↑ Accumulates: lactate
Presentation: rare lactic acidosis, mainly with renal failure or overdose; T2DM first-line agent
Labs: ↑ lactate
Treatment: Hold for contrast procedures; contraindicated eGFR <30
Learn the mechanism: Electron transport & OXPHOS →
FMK 02.4 Mitochondrial Metabolism and Energy Disorders · slide 17, 23; FMK 03.1 slide 10; FMK 02.1 slide 21