Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Glycogen · FMK 01.2
McArdle disease (glycogen storage disease type V) Autosomal recessive
Defect / target: Muscle glycogen phosphorylase (myophosphorylase)
Mechanism: Muscle cannot mobilize glycogen during exercise so glycogen (normal structure) accumulates and no lactate is produced; liver phosphorylase is intact so blood glucose stays normal.
↑ Accumulates: Glycogen in skeletal muscle· ↓ Deficient: Glucose-1-phosphate from muscle glycogen during exercise
Presentation: exercise intolerance, muscle cramps, myoglobinuria after strenuous exercise, 'second wind' at 8–10 min (switch to blood glucose + FFA)
Labs: no rise in blood lactate during forearm exercise test, ↑ CK, normal blood glucose
Treatment: aerobic warm-up, pre-exercise oral glucose (sucrose 20–40 g)
McArdle = Muscle
Learn the mechanism: Glycogen synthesis & breakdown →Reasoning case →
FMK 01.2 Proteins, Carbohydrates, Lipids; FMK 03.6 Glycogen Metabolism · slide 01.2: 10; 03.6: 22, 25, 26, 29, 30