Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 05.6
Jamaican vomiting sickness (hypoglycin toxicity) Acquired / not inherited
Defect / target: Hypoglycin A (unripe ackee fruit) inhibits acyl-CoA dehydrogenases
Mechanism: The toxin blocks β-oxidation, mimicking an inherited FAO disorder with fasting hypoketotic hypoglycemia and vomiting.
↑ Accumulates: acylcarnitines· ↓ Deficient: ketones, glucose
Presentation: vomiting, hypoketotic hypoglycemia — a mimic of mitochondrial FAO disorders
Labs: hypoketotic hypoglycemia
Mimics to know for FAO disorders: Jamaican vomiting sickness (hypoglycin) and Reye syndrome (aspirin + viral illness)
Learn the mechanism: Lipolysis, carnitine shuttle & β-oxidation →
FMK 05.6 Fatty Acid Metabolism II · slide 18