Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Heme · FMK 08.4
Intrahepatic cholestasis Acquired / not inherited
Defect / target: Impaired canalicular secretion of conjugated bilirubin within the liver
Mechanism: Bilirubin is conjugated normally but poorly secreted into bile, so conjugated bilirubin regurgitates back into the blood.
↑ Accumulates: Conjugated bilirubin in plasma and urine· ↓ Deficient: Bilirubin in bile
Presentation: Jaundice, dark urine, pruritus
Labs: Conjugated hyperbilirubinemia, cholestatic enzyme pattern (ALP/GGT)
Treatment: Treat underlying cause
Learn the mechanism: Heme degradation & bilirubin (jaundice) →
FMK 08.4 Heme Metabolism · slide handout