Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Heme · FMK 08.4
Hereditary spherocytosis (as cause of hemolytic jaundice) Autosomal dominant
Defect / target: RBC membrane skeleton proteins (spectrin/ankyrin)
Mechanism: Spherical, poorly deformable RBCs are trapped and destroyed in the spleen, producing extravascular hemolysis and unconjugated hyperbilirubinemia.
↑ Accumulates: Unconjugated bilirubin, urobilinogen
Presentation: Hemolytic anemia, jaundice, splenomegaly, pigment gallstones
Labs: Elevated unconjugated bilirubin, spherocytes on smear
Learn the mechanism: Heme degradation & bilirubin (jaundice) →
FMK 08.4 Heme Metabolism · slide 26