Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.4
IV hemin (hematin) for acute porphyria Acquired / not inherited
Defect / target: Drug target: hepatic ALAS1 (heme feedback repression)
Mechanism: Exogenous heme repletes the hepatic free heme pool, restoring repression of ALAS1 transcription and mitochondrial import, which shuts off ALA/PBG overproduction at its source.
Presentation: Mainstay treatment for acute neurovisceral porphyria attacks (AIP, HCP, VP)
Labs: Falling urinary ALA/PBG with treatment
'Give glucose and hemin, avoid inducers'
Learn the mechanism: Heme synthesis (porphyrias) →
FMK 08.4 Heme Metabolism · slide 18; handout