Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 02.4
2,4-Dinitrophenol (DNP) toxicity Acquired / not inherited
Defect / target: Uncoupler — hydrophobic weak acid that shuttles H⁺ across the inner membrane, bypassing ATP synthase
Mechanism: DNP dissipates the proton gradient so the ETC runs (O₂ consumed) but energy is released as heat rather than ATP.
↑ Accumulates: heat· ↓ Deficient: ATP
Presentation: hyperthermia (>40°C), tachycardia, diaphoresis, rapid weight loss, death; 1930s diet pill still sold online
Labs: ↑ temperature, metabolic acidosis, ↑ O₂ consumption
Treatment: Cooling, supportive care
Learn the mechanism: Electron transport & OXPHOS →
FMK 02.4 Mitochondrial Metabolism and Energy Disorders · slide 13, 14, 25