Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Signaling · FMK 03.6
Hypoglycemia in counter-regulatory hormone deficiency (glucagon, epinephrine/adrenal insufficiency, cortisol) Acquired / not inherited
Defect / target: Glucagon deficiency (absent PKA cascade), epinephrine deficiency (adrenal insufficiency), cortisol deficiency
Mechanism: Without glucagon the PKA cascade cannot activate glycogenolysis; without epinephrine glycogen is not mobilized under stress; without cortisol gluconeogenesis and insulin counter-regulation are impaired.
↑ Accumulates: glycogen (unmobilized)· ↓ Deficient: blood glucose during fasting/stress
Presentation: fasting or stress hypoglycemia; patients especially sensitive to fasting or stress
Labs: hypoglycemia
Learn the mechanism: Glycogen synthesis & breakdown →Reasoning case →
FMK 03.6 Glycogen Metabolism · slide 27