Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Glycogen · FMK 03.6
Cori disease (GSD Type III) Autosomal recessive
Defect / target: Debranching enzyme (4:4 transferase + amylo-α-1,6-glucosidase)
Mechanism: Phosphorylase stops 4 residues from each branch and the stubs cannot be removed, so limit dextrin accumulates; gluconeogenesis is intact so hypoglycemia is milder than GSD I.
↑ Accumulates: limit dextrin (abnormal glycogen with short outer chains)
Presentation: milder fasting hypoglycemia, hepatomegaly, growth retardation, possible muscle weakness
Labs: elevated liver enzymes, mild hypoglycemia, abnormal glycogen structure
'Cori = Cuts off at branches'
Learn the mechanism: Glycogen synthesis & breakdown →
FMK 03.6 Glycogen Metabolism · slide 22, 25, 30