Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Signaling · FMK 05.1
Congenital adrenal hyperplasia (21α-hydroxylase deficiency) Autosomal recessive
Defect / target: 21α-hydroxylase (most common CAH, ~90%+)
Mechanism: Block in the glomerulosa and fasciculata branches prevents aldosterone and cortisol synthesis; precursors back up and are shunted to the androgen branch, while loss of cortisol feedback raises ACTH and hyperplasia.
↑ Accumulates: 17-hydroxyprogesterone/progesterone precursors, adrenal androgens (DHEA, testosterone), ACTH· ↓ Deficient: cortisol, aldosterone
Presentation: salt-wasting, virilization
Labs: ↓ cortisol, ↓ aldosterone
CAH = a block anywhere on the steroid map: what's missing downstream, what backs up upstream
Learn the mechanism: Cholesterol synthesis →
FMK 05.1 Cholesterol & Steroid Synthesis · slide 19, 25