Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 06.1
Carbon monoxide (CO) poisoning Acquired / not inherited
Defect / target: CO binds hemoglobin heme ~220× more tightly than O₂, forming carboxyhemoglobin (HbCO)
Mechanism: CO locks the tetramer toward the R state, raising the remaining subunits' O₂ affinity (left shift, more hyperbolic curve) so hemoglobin will not release the O₂ it carries — tissue delivery collapses despite adequate O₂ content.
↑ Accumulates: Carboxyhemoglobin· ↓ Deficient: Tissue O₂ delivery
Presentation: Found unconscious in a running car in a closed garage, cherry-red skin, barely breathing/unresponsive, pulse oximeter falsely reads 98%
Labs: Normal-appearing pulse oximetry despite tissue hypoxia; HbCO level
Treatment: 100% O₂ or hyperbaric O₂ — mass action competes CO off hemoglobin and shortens HbCO half-life
Cherry-red, pulse ox 98%, still suffocating — left-shifted, hyperbolic curve
Learn the mechanism: Electron transport & OXPHOS →
FMK 06.1 Protein Structure & Function I; FMK 02.4 Mitochondrial Metabolism and Energy Disorders; FMK 08.4 Heme Metabolism · slide 06.1: 2, 23; 02.4: 9, 11, 17, 20, 25; 08.4: 6, 20