Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 01.5
Aspirin (irreversible COX suicide inhibition / toxicity) Acquired / not inherited
Defect / target: Cyclooxygenase COX-1 and COX-2 (irreversibly acetylated)
Mechanism: Aspirin covalently acetylates the COX active site, permanently blocking prostaglandin (and thromboxane) production.
· ↓ Deficient: Prostaglandins, thromboxane A2
Presentation: Analgesic/anti-inflammatory/antiplatelet effects; toxicity: tinnitus, hyperventilation, mixed respiratory alkalosis + metabolic acidosis, GI bleeding
Labs: Salicylate level; mixed acid-base disturbance in overdose
Treatment: Alkalinize urine, dialysis in severe toxicity
Suicide inhibitor kinetics resemble non-competitive when enzyme > inhibitor
Learn the mechanism: Eicosanoids (COX / LOX) →
FMK 01.5 Enzyme Kinetics, Regulation and Inhibition · slide 2, 16