Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 02.1
Arsenic poisoning Acquired / not inherited
Defect / target: Arsenite (As³⁺) binds SH groups of lipoic acid (PDH, α-KG DH, BCKA DH); arsenate (As⁵⁺) substitutes for Pi at G3P dehydrogenase
Mechanism: Arsenite inactivates the lipoic-acid-dependent dehydrogenases so pyruvate cannot enter the TCA cycle, while arsenate forms 1-arseno-3-PG that hydrolyzes spontaneously, bypassing 1,3-BPG and eliminating ATP production at the phosphoglycerate kinase step.
↑ Accumulates: pyruvate, lactate· ↓ Deficient: ATP, acetyl-CoA
Presentation: GI symptoms (vomiting, rice-water stools), peripheral neuropathy, Mees' lines on nails, hypotension, cardiovascular collapse, encephalopathy
Treatment: Chelation (dimercaprol / DMSA)
Learn the mechanism: Glycolysis →
FMK 02.1 Glucose Transport, Glycolysis & TCA · slide 23, 24