Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.1
Allopurinol Acquired / not inherited
Defect / target: Hypoxanthine analog that inhibits xanthine oxidase
Mechanism: Blocks oxidation of hypoxanthine to xanthine and xanthine to uric acid, so the more soluble hypoxanthine and xanthine accumulate and are excreted in urine instead of insoluble uric acid.
↑ Accumulates: Hypoxanthine, xanthine (soluble, excreted)· ↓ Deficient: Uric acid
Presentation: Long-term therapy for over-producers of uric acid (gout, Lesch-Nyhan urate manifestations)
Labs: Lowers serum uric acid
Allopurinol treats the urate of Lesch-Nyhan, not the neurology
Learn the mechanism: Purine degradation & uric acid →
FMK 08.1 Nucleic Acid Metabolism · slide 20, 28