Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Toxin/Drug · FMK 08.1
Acute gout anti-inflammatory therapy (colchicine, NSAIDs, glucocorticoids) Acquired / not inherited
Defect / target: Colchicine (microtubule inhibitor), NSAIDs such as indomethacin (COX inhibitors), glucocorticoids such as prednisolone
Mechanism: Target the inflammatory response to MSU crystals during an acute attack, not uric acid levels themselves.
Presentation: Used for: the acute gouty attack (hot, swollen first MTP) — colchicine, NSAIDs (indomethacin) or glucocorticoids; they do not lower urate
Acute attack = treat inflammation; long-term = treat urate
Learn the mechanism: Purine degradation & uric acid →
FMK 08.1 Nucleic Acid Metabolism · slide 20, 28