Learn / FMK
Every FMK condition
299 diseases, deficiencies, toxicities and drug mechanisms harvested from every FMK deck — the ones sprinkled through a single bullet as much as the ones with their own slide. Pick what you're given and what you have to name, or let it cycle; distractors come from the same category so you have to discriminate (hypoketotic vs. ketotic hypoglycemia, which GSD, which urea-cycle enzyme…). Every answer shows the whole card with the lecture and slide.
Lipid · FMK 04.4
Abetalipoproteinemia Autosomal recessive
Defect / target: Microsomal triglyceride transfer protein (MTP)
Mechanism: Without MTP, lipid cannot be loaded onto apo B-48/B-100 so no chylomicrons or VLDL are assembled; lipid and fat-soluble vitamins accumulate in enterocytes/hepatocytes instead of being secreted.
↑ Accumulates: lipid in enterocytes and hepatocytes· ↓ Deficient: chylomicrons, VLDL, LDL, plasma cholesterol/TAG, vitamin E (and other fat-soluble vitamins)
Presentation: fat malabsorption, steatorrhea, vomiting, failure to thrive, vitamin E deficiency (ataxia, areflexia)
Labs: acanthocytes on smear, very low cholesterol and TAG
Pharmacologic parallel: MTP inhibitor lomitapide — same mechanism, therapeutic intent
Learn the mechanism: Lipid digestion & absorption →
FMK 04.4 Lipid Digestion, Transport & Storage · slide 12, 28